Gene TIMP1 map

Identifiers
HUGO:TIMP1
TIMP metallopeptidase inhibitor 1
"tissue inhibitor of metalloproteinase 1"
HUGO:TIMP1 HGNC:11820 ENTREZ:7076 UNIPROT:P01033

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / MATRIX_REGULATION  map
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
CASCADE:TGFB
CASCADE:IL6
CASCADE:LIF
CASCADE:IL1
PMID:11279127
Dominant-Negative Smad3 and Inhibitory Smad7 Expression Block TGF-??-induced ECM Promoter Activation in fibroblasts
COL1A2, COL3A1, COL6A1, COL6A3, and TIMP-1
PMID:8515078; PMID:8559663
OMS, IL-6, LIF, and IL-1 alpha elevated the TIMP-1 expression at the RNA level in fibroblasts
probably via STAT3
PMID:16834928
TIMP1 expression in fibroblasts is STAT3 dependent

Modifications:
In compartment: Cytosol
  1. gTIMP1@Cytosol map
In compartment: Nucleus
  1. gTIMP1@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gTIMP1@Cytosol map → map rTIMP1@Cytosol map
    2. gTIMP1@Nucleus map → map rTIMP1@Nucleus map
    As Catalyser: