Protein SESN2 map

Identifiers
sestrin 2
HUGO:SESN2 HGNC:20746 ENTREZ:83667 UNIPROT:P58004

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / FATTY_ACID_BIOSYNTHESIS  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / RCD_GENES  map

SESN2@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / FATTY_ACID_BIOSYNTHESIS  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / RCD_GENES  map

References
rc_re334( Regulated Cell Death  map ):
PMID:15509864
review
PMID:16054095
by CAMKK2
PMID:16054096
PMID:17244528
by calcium via CAMKK2 and AMPK
PMID:15980064
by CAMKK
PMID:18692468
propose that SESN2 promotes AMPK autophosphorylation, thus increasing TSC1/2 activity.
PMID:19197243
in RPE1-hTERT mouse inner medullary collecting duct cells, in MEFs, in MCF10A, by TAK1, upon TRAIL exposure
in MCF10A upon Ca2+ by CAMKK2
High Calcium lvl activate CAMKK2 enzyme and leads to AMPK activation
PMID:19037093PMID:17244528
PMID:20484410
rc_re352( Regulated Cell Death  map ):
PMID:14651849
PMID:19339977
SESN2 promotes TSC2 phosphorylation, and interacts with both AMPK and TSC2.

Modifications:
In compartment: Cytosol
  1. SESN2@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rSESN2@Nucleus map → map SESN2@Cytosol map
    As Catalyser:
    1. AMP:​PKA_R*:​PRKAA*:​PRKAG*@Cytosol map → map AMP:​PKA_R*:​PRKAA*|​T172_pho:​PRKAG*@Cytosol map
    2. TSC1:​TSC2|​M1_unk@Cytosol map → map TSC1:​TSC2|​S1345_pho|​M1_unk@Cytosol map