Protein p85* map

Identifiers
HUGO:PIK3R1 HGNC:8979 ENTREZ:5295 UNIPROT:P27986 GENECARDS:PIK3R1 HUGO:PIK3R2 HGNC:8980 ENTREZ:5296 UNIPROT:O00459 GENECARDS:PIK3R2 HUGO:PIK3R3 HGNC:8981 ENTREZ:8503 UNIPROT:Q92569 GENECARDS:PIK3R3

Maps_Modules
MODULE:MACROPHAGE
MODULE:CORE_SIGNALING_PATHWAYS

References
REACTOME:61192 KEGG:5295 ATLASONC:PIK3R1ID41717ch5q13 WIKI:PIK3R1
REACTOME:61194 KEGG:5296 ATLASONC:GC_PIK3R2 WIKI:PIK3R2
REACTOME:61182 KEGG:8503 ATLASONC:GC_PIK3R3 WIKI:PIK3R3
PMID:11687500
The class IA PI3Ks, which transmit signals from tyrosine kinase-coupled receptors, are heterodimeric proteins having a p110 catalytic subunit associated with a p85, p55, or p50 regulatory subunit.
PMID:19109239
Activated IRS2 interacts with Grb2 and activates PI3K signaling downstream of IL4.
PMID:18250477
Galectin 3 mediate alternative activation of macrophages via activation of PI3K signaling and AKT posphorylation. And regulates expression of MRC1 probably via PI3K.

p85*@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. p85*@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. p110*:​p85*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. p85*@Cytosol map → map p85*@Cytosol map
  2. p110*@Cytosol map + p85*@Cytosol map → map p110*:​p85*@Cytosol map
As Catalyser:
  1. STAT6@Cytosol map → map STAT6|​pho|​active@Cytosol map
  2. PIP2*@Cytosol map → map PIP3*@Cytosol map