Protein MIF map

Identifiers
HUGO:MIF

Maps_Modules
MODULE:MACROPHAGE
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS

References
PMID:23390297, PMID:22461508, PMID:8195715
MIF is expresed by macrophages
PMID:23390297, PMID:22461508
MIF signaling induces angiogenesis provavly via upregulation of MMP9, VEGF expression and activates tumor invasion.
PMID:23390297
MIF inhitits expression of M1 markers such as TNF, IL12p40, COX2, INOS, IRF-5, MHC-II, CD11c, CD80, CD86.
MIF induces expression of M2 markers ARG1, IL10, stabilin-1, MRC-1, CD206, CD23.

MIF@default

Identifiers

Maps_Modules

References

MIF@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. MIF@Cytosol map
In compartment: default
  1. MIF@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rMIF@Cytosol map → map MIF@Cytosol map
    2. MIF@Cytosol map → map MIF@default map
    3. MIF@default map → map Tumor invasion@Membrane map
    As Catalyser:
    1. gTNF@Cytosol map → map rTNF@Cytosol map
    2. gARG1@Cytosol map → map rARG1@Cytosol map
    3. gMHC class II*@Cytosol map → map rMHC class II*@Cytosol map
    4. gMRC1@Cytosol map → map rMRC1@Cytosol map
    5. gVEGFA@Cytosol map → map rVEGFA@Cytosol map
    6. rTLR4@Cytosol map → map TLR4@Membrane map
    7. gCD80@Cytosol map → map rCD80@Cytosol map
    8. gCD86@Cytosol map → map rCD86@Cytosol map
    9. gPTGS2@Cytosol map → map rPTGS2@Cytosol map
    10. gIRF5@Cytosol map → map rIRF5@Cytosol map
    11. gSTAB1@Cytosol map → map rSTAB1@Cytosol map
    12. gFCER2@Cytosol map → map rFCER2@Cytosol map
    13. gIL12p40*@Cytosol map → map rIL12p40*@Cytosol map
    14. gNOS2@Cytosol map → map rNOS2@Cytosol map
    15. gMMP9@Cytosol map → map rMMP9@Cytosol map