Identifiers
RAS p21 protein activator (GTPase activating protein) 1
RASA
HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / CYTOSKELETON_POLARITY 

References
PMID:8537347
PMID:10769036
GAP activity of ARHGAP5 is abrogated by binding to RASA1 (p120GAP)
PMID:8360177
RASA1 is a GAP for HRAS.
PMID:18829532
RasGAP actvity of RASA1 is reduced when associated with ARHGAP35 which is a specific GAP for RhoA

References
em_emtc_emtc_re897( EMT Senescence  ):
PMID:8537347
PMID:10769036
GAP activity of ARHGAP5 is abrogated by binding to RASA1 (p120GAP)
em_emtc_emtc_re934( EMT Senescence  ):
PMID:8360177
RASA1 is a GAP for HRAS.
PMID:18829532
RasGAP actvity of RASA1 is reduced when associated with ARHGAP35 which is a specific GAP for RhoA
ARHGAP35 is tyrosine-phosphorylated.
The association of ARHGAP35 (p190) with RASA1 (p120) is promoted and stabilized by phosphorylation of p190 at Y1105 by PTK6..

1. RASA1@Cytosol

1. ARHGAP5:​RASA1@Cytosol
2. ARHGAP35|​pho:​RASA1@Cytosol

1. RASA1@Cytosol + ARHGAP5@Cytosol → ARHGAP5:​RASA1@Cytosol
2. HRAS_GAPs*@Cytosol → RASA1@Cytosol
3. ARHGAP35|​pho@Cytosol + RASA1@Cytosol → ARHGAP35|​pho:​RASA1@Cytosol