Reaction state_transition rc_re8 map

Mitochondria outer~membrane integrity@Mitochondrial inner membrane map → MOMP@Mitochondrial inner membrane map

Reaction regulators:
Catalysis
  1. rc_s11
  2. rc_s4588
  3. BCL2-XL*:​Cleaved ATG5*@Cytosol map
  4. PAR Polymer@Nucleus map
Unknown_catalysis
  1. cleaved~BECN1*@Mitochondrial inner membrane map


References
in Ba/F3 cells, stable expression of the C-terminal cleavage product of BECN1 sensitizes cells to IL3-deprivation induced apoptosis
in vitro, incubation of isolated mitochondria with recombinant BECN1 C-terminal cleavage product triggers release of Omi/HtrA2 and cytochrome c
PMID:11832478
in vitro CASP2 unlike CASP8 induce release of CYCS , DIABLO and AIF form purified mitochondria from Hela cellsPMID: PMID:23242420
calpain-mediated Bax and Atg5 cleavage resulted in the collapse of the mitochondrial membrane potential and cytochrome c release