Identifiers
HUGO:SMAD7
SMAD family member 7
"MAD, mothers against decapentaplegic homolog 7 (Drosophila)", MADH7, MADH8, "SMAD, mothers against DPP homolog 7 (Drosophila)"
HUGO:SMAD7 HGNC:6773 ENTREZ:4092 UNIPROT:O15105
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / GROWTH_FACTORS_SIGNALING_PATHWAYS
EMT Senescence / EMT_REGULATORS
References
PMID:23784029
mature??miR-21??increases after TGF-??1 treatment, whereas the??Smad??7??protein level decreases.??MiR-21??binds to the 3' UTR of Smad7 mRNA and inhibits its translation, rather than causing its degradation. Most importantly,??Smad??7??is bound to??Smad??2 and 3, which are thought to competitively bind to TGFBR1, and prevents their activation upon TGF-??1 stimulation. The depletion of??miR-21??or the overexpression of??Smad??7??blocks TGF-??1-induced??CAF??formation, whereas the overexpression of??miR-21??or the depletion of??Smad??7??promotes??CAF??formation, even without TGF-??1 stimulation.
References
em_emtc_emtc_re210( EMT Senescence ):
PMID:9335507
TGFB rapidly induces expression of Smad7 mRNA, suggesting that Smad7 may participate in a negative feedback loop to control TGFB responses.
em_emtc_emtc_re1165( EMT Senescence ):
PMID:22286770
inhibitory Smad7 mRNA is a target for all 3 members of MIR106B/25 subfamily (MIR106B, MIR93, MIR25)
→ rSMAD7@Cytosol
→ SMAD7@Cytosol
+ rSMAD7@Cytosol → MIR21:SMAD7@Cytosol
→ degraded
+ rSMAD7@Nucleus → em_emtc_emtc_s3753
→ rSMAD7@Nucleus
→ SMAD7@Cytosol