Antisense RNA MIR21 map

Identifiers
HUGO:MIR21
microRNA 21
HUGO:MIR21, HGNC:31586, ENTREZ:406991, GENECARDS:GC17P057918
HUGO:MIR21 HGNC:31586 ENTREZ:406991

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_SIGNALING_PATHWAYS  map
 Cancer Associated Fibroblasts  map  / CORE  map
 EMT Senescence  map  / EMT_REGULATORS  map

References
CASCADE:TGFB
PMID:23784029
mature??miR-21??increases after TGF-??1 treatment, whereas the??Smad??7??protein level decreases.??MiR-21??binds to the 3' UTR of Smad7 mRNA and inhibits its translation, rather than causing its degradation. Most importantly,??Smad??7??is bound to??Smad??2 and 3, which are thought to competitively bind to TGFBR1, and prevents their activation upon TGF-??1 stimulation. The depletion of??miR-21??or the overexpression of??Smad??7??blocks TGF-??1-induced??CAF??formation, whereas the overexpression of??miR-21??or the depletion of??Smad??7??promotes??CAF??formation, even without TGF-??1 stimulation.
PMID:23138871
PMID:19962668

arMIR21@Nucleus

References
mo_re193:( motility  map ) PMID:22677902

Modifications:
In compartment: Cytosol
  1. arMIR21@Cytosol map
In compartment: Nucleus
  1. arMIR21@Nucleus map
Participates in complexes:
In compartment: Cytosol
  1. MIR21:​SMAD7@Cytosol map
In compartment: Nucleus
  1. MIR21:​PTEN@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. arMIR21@Cytosol map + rSMAD7@Cytosol map → map MIR21:​SMAD7@Cytosol map
  2. gMIR21@Cytosol map → map arMIR21@Cytosol map
  3. MIR21:​SMAD7@Cytosol map → map degraded
  4. gMIR21@Nucleus map → map arMIR21@Nucleus map
  5. gMIR21@Nucleus map → map arMIR21@Nucleus map
  6. arMIR21@Nucleus map + rPTEN@Nucleus map → map MIR21:​PTEN@Nucleus map
As Catalyser:
  1. rPTEN@Nucleus map → map PTEN@Nucleus map
  2. rPTEN@Nucleus map → map PTEN@Cytosol map
  3. rPDCD4@Nucleus map → map PDCD4@Cytosol map
  4. rFASL@Nucleus map → map FASLG@Cytosol map