Antisense RNA MIR106B_25* map

Identifiers
microRNA 106b
HUGO:MIR106B, HGNC:31495, ENTREZ:406900, GENECARDS:GC07M099695

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map

References
Homeoprotein Six1 increases TGF-beta type I receptor and converts TGF-beta signaling from suppressive to supportive for tumor growth
PMID:19726885
PMID:22286770
PMID:21386132
The miR-17 family consists of 3 paralogous polycistronic clusters on different chromosomes:
miR-17/92 (miR-17, miR-18a, miR-19a, miR-20a, miR-19b- 1, and miR-92a-1),
miR-106b/25 (miR-106b, miR-93, and miR-25) and
miR-106a/363 (miR-106a, miR-18b, miR-20b, miR-19b-2, miR-92a-2, and miR-363).

arMIR106B_25*@Nucleus

References
em_emtc_emtc_re362( EMT Senescence  map ):
PMID:22945800
PMID:22286765
Six1 induces ZEB1 and EMT through transcriptional repression of miR200.
PMID:22286770
miR-106b, miR-93 and miR-25 are overexpressed in Six1 transgenic mammary glands as compared with control mammary
em_emtc_emtc_re1165( EMT Senescence  map ):
inhibitory Smad7 mRNA is a target for all 3 members of MIR106B/25 subfamily (MIR106B, MIR93, MIR25)

Modifications:
In compartment: Nucleus
  1. arMIR106B_25*@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. arMIR106B_25*@Nucleus map → map arMIR106B@Nucleus map
    2. arMIR106B_25*@Nucleus map → map arMIR93@Nucleus map
    3. arMIR106B_25*@Nucleus map → map arMIR25@Nucleus map
    4. arMIR106B_25*@Nucleus map + rSMAD7@Nucleus map → map em_emtc_emtc_s3753
    5. gMIR106B_25*@Nucleus map → map arMIR106B_25*@Nucleus map
    As Catalyser: