Identifiers
NAME:MIR21:SMAD7
References
PMID:23784029
mature??miR-21??increases after TGF-??1 treatment, whereas the??Smad??7??protein level decreases.??MiR-21??binds to the 3' UTR of Smad7 mRNA and inhibits its translation, rather than causing its degradation. Most importantly,??Smad??7??is bound to??Smad??2 and 3, which are thought to competitively bind to TGFBR1, and prevents their activation upon TGF-??1 stimulation. The depletion of??miR-21??or the overexpression of??Smad??7??blocks TGF-??1-induced??CAF??formation, whereas the overexpression of??miR-21??or the depletion of??Smad??7??promotes??CAF??formation, even without TGF-??1 stimulation.