Identifiers
SMAD family member 7
HUGO:SMAD7 hgnc_id:HGNC:6773 HGNC:6773 ENTREZ:4092 UNIPROT:O15105
"MAD, mothers against decapentaplegic homolog 7 (Drosophila)", MADH7, MADH8, "SMAD, mothers against DPP homolog 7 (Drosophila)"
HUGO:SMAD7 HGNC:6773 ENTREZ:4092 UNIPROT:O15105
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CAF_INHIBITION_ANTITUMOR
EMT Senescence / EMT_REGULATORS
References
CASCADE:TGFB
_INHIBITION_ANTITUMOR
PMID:15265520,PMID:14722617
SMAD7 has been shown to interact with the E3 ubiquitin ligases Smurf 1 and Smurf 2, recruiting them to T??R complexes and inducing the degradation of activated T??RI [20] and [21].
PMID:11279127
Dominant-Negative Smad3 and Inhibitory Smad7 Expression Block TGF-??-induced ECM Promoter Activation in fibroblasts
PMID:23784029
mature??miR-21??increases after TGF-??1 treatment, whereas the??Smad??7??protein level decreases.??MiR-21??binds to the 3' UTR of Smad7 mRNA and inhibits its translation, rather than causing its degradation. Most importantly,??Smad??7??is bound to??Smad??2 and 3, which are thought to competitively bind to TGFBR1, and prevents their activation upon TGF-??1 stimulation. The depletion of??miR-21??or the overexpression of??Smad??7??blocks TGF-??1-induced??CAF??formation, whereas the overexpression of??miR-21??or the depletion of??Smad??7??promotes??CAF??formation, even without TGF-??1 stimulation.
→ SMAD7@Cytosol
+ SMAD7@Cytosol → SMAD2:SMAD7@Cytosol
+ SMAD7@Cytosol → SMAD3:SMAD7@Cytosol
→ NEGATIVE_REGULATORS OF_CAF@Cytosol
+ SMAD7@Cytosol → em_emtc_emtc_s3754
→ SMAD7@Cytosol
→ SMAD7@Cytosol