Complex CBF1*:NICD* map
Complex composition:

  1. NICD* map
  2. CBF1* map

CBF1*:​NICD*@Nucleus

Identifiers
NAME:CBF1*:NICD*

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map

References
em_emtc_emtc_re1363( EMT Senescence  map ):
PMID:14976548
TGFB stimulates two kinetically coordinated waves of activation of HEY1.
Immediate-early activation of HEY1 by TGFB is mediated directly by Smad3/4 binding at two distinct sequences in the distal HEY1 promoter region and does not require Notch signalling.
The Smad-dependent, Notch-independent immediate-early activation is followed by a second wave of HEY1 activation.
This second wave is mediated by classical Notch-dependent signalling induced through indirect and delayed induction of Jag1 synthesis by TGFB

Modifications:
Participates in complexes:
In compartment: Nucleus
  1. CBF1*:​NICD*@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. NICD*@Nucleus map + CBF1*@Nucleus map → map CBF1*:​NICD*@Nucleus map
As Catalyser:
  1. gHEY1@Nucleus map → map rHEY1@Nucleus map
  2. gHEY2@Nucleus map → map rHEY2@Nucleus map