Reaction transcription em_emtc_emtc_re1363 map

gHEY1@Nucleus map → rHEY1@Nucleus map

Reaction regulators:
Physical_stimulation
  1. CBF1*:​NICD*@Nucleus map
  2. (SMAD3|​S423_pho|​S425_pho|​hm2:​SMAD4)|​active@Nucleus map


References
PMID:14976548
TGFB stimulates two kinetically coordinated waves of activation of HEY1.
Immediate-early activation of HEY1 by TGFB is mediated directly by Smad3/4 binding at two distinct sequences in the distal HEY1 promoter region and does not require Notch signalling.
The Smad-dependent, Notch-independent immediate-early activation is followed by a second wave of HEY1 activation.
This second wave is mediated by classical Notch-dependent signalling induced through indirect and delayed induction of Jag1 synthesis by TGFB