Identifiers
hes-related family bHLH transcription factor with YRPW motif 1
HUGO:HEY1, HGNC:4880, ENTREZ:23462, UNIPROT:Q9Y5J3, GENECARDS:GC08M080676
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
References
em_emtc_emtc_re1363( EMT Senescence ):
PMID:14976548
TGFB stimulates two kinetically coordinated waves of activation of HEY1.
Immediate-early activation of HEY1 by TGFB is mediated directly by Smad3/4 binding at two distinct sequences in the distal HEY1 promoter region and does not require Notch signalling.
The Smad-dependent, Notch-independent immediate-early activation is followed by a second wave of HEY1 activation.
This second wave is mediated by classical Notch-dependent signalling induced through indirect and delayed induction of Jag1 synthesis by TGFB