Protein cIAP* map

Identifiers
HUGO:BIRC2
HUGO:BIRC3
cytokine induced apoptosis inhibitor 1
HUGO:CIAPIN1 HGNC:28050 ENTREZ:57019 UNIPROT:Q6FI81
baculoviral IAP repeat containing 2
HUGO:BIRC2 HGNC:590 ENTREZ:329 UNIPROT:Q13490
baculoviral IAP repeat containing 3
HUGO:BIRC3 HGNC:591 ENTREZ:330 UNIPROT:Q13489
HUGO:BIRC2 HUGO:BIRC3

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / INFLAMMATORY_SIGNALING_PATHWAYS  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / TNF_RESPONSE  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map

References
PMID:21232017, PMID:17301840
cIAP1 and cIAP2 modify RIP1, TRAF2 and themselves with K63-linked ubiquitin chains. This creates docking sites for the LUBAC complex, an E3 ligase capable of forming linear polyubiquitin chains.
PMID:23070005
PMID:21232017, PMID:21133840, PMID:17301840

cIAP*|​ubi@TNFRSF1 Receptor Complex

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / TNF_RESPONSE  map

References
rc_re1160( Regulated Cell Death  map ):
PMID:18022362
SMAC mimetic induces cIAP auto-ubiquitinylation and degradation
PMID:18022363

cIAP*@TNFRSF1 Receptor Complex

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / TNF_RESPONSE  map

References
rc_re1160( Regulated Cell Death  map ):
PMID:18022362
SMAC mimetic induces cIAP auto-ubiquitinylation and degradation
PMID:18022363
rc_re1210( Regulated Cell Death  map ):
PMID:18570872
PMID:18621737
PMID:23010170
Complex I-mediated NF-??B stimulation is caused by cIAP-induced
K63-linked polyubiquitination of RIP1 and linear ubiquitin chain
assembly complex (LUBAC)-mediated linear ubiquitination of
RIP1

Modifications:
In compartment: Cytosol
  1. cIAP*@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. cIAP*@INNATE_IMMUNE_CELL_Cytosol map
In compartment: TNFRSF1 Receptor Complex
  1. cIAP*@TNFRSF1 Receptor Complex map
  2. cIAP*|​ubi@TNFRSF1 Receptor Complex map
Participates in complexes:
In compartment: TNFRSF1 Receptor Complex
  1. XAF1:​cIAP*@TNFRSF1 Receptor Complex map
Participates in reactions:
As Reactant or Product:
  1. BIRC2@Cytosol map → map cIAP*@Cytosol map
  2. BIRC3@Cytosol map → map cIAP*@Cytosol map
  3. BIRC2@INNATE_IMMUNE_CELL_Cytosol map → map cIAP*@INNATE_IMMUNE_CELL_Cytosol map
  4. BIRC3@INNATE_IMMUNE_CELL_Cytosol map → map cIAP*@INNATE_IMMUNE_CELL_Cytosol map
  5. BIRC3@Cytosol map → map cIAP*@Cytosol map
  6. BIRC2@Cytosol map → map cIAP*@Cytosol map
  7. cIAP*@TNFRSF1 Receptor Complex map → map cIAP*|​ubi@TNFRSF1 Receptor Complex map
  8. cIAP*|​ubi@TNFRSF1 Receptor Complex map → map degraded
  9. cIAP*@Cytosol map → map cIAP*@TNFRSF1 Receptor Complex map
  10. cIAP*@TNFRSF1 Receptor Complex map + XAF1@TNFRSF1 Receptor Complex map → map XAF1:​cIAP*@TNFRSF1 Receptor Complex map
As Catalyser:
  1. FADD:​RIPK1:​TNF:​TNFR1*:​TRADD:​TRAF2@Cytosol map → map FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@Cytosol map
  2. RIPK1@TNFRSF1 Receptor Complex map → map RIPK1|​K377_ubi@TNFRSF1 Receptor Complex map