Phenotype Cytoskeleton remodeling map
Cytoskeleton remodeling@Cytosol

References
mo_re65:( motility  map ) PMID:18078820

Cytoskeleton remodeling@Nucleus

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

References
em_emtc_emtc_re777( EMT Senescence  map ):
RAC1 modulates cytoskeleton remodeling by activating ARFP2 and PIP5K1
PMID:9312003
ARFP2 functions as an important regulatory element in orchestrating cytoskeletal rearrangements at the cell periphery induced by ARF6 and Rac1
em_emtc_emtc_re782( EMT Senescence  map ):
PMID:10679324
Rac-associated PIP 5-kinase as the PIP 5-kinase isoforms alpha and beta.
When added to permeabilized platelets, PIP 5-kinase alpha induced actin filament uncapping and assembly.
PIP 5-kinase alpha is a critical mediator of thrombin- and Rac-dependent actin assembly.
PMID:14681219
PIP5K catalyzes the formation of the phospholipid, phosphatidylinositol 4,5-bisphosphate PIP2
RhoA and Rac1 bind and activate PIP5K.
3 isoforms of type I PIP5K (alpha,beta, and gamma) have been identified
RhoA and Rac1, as well as Cdc42, but not RalA and Rap1A, markedly stimulate PIP2 synthesis by all three PIP5K isoforms expressed in human embryonic kidney 293 cells, both in vitro and in vivo.
RhoA-stimulated PIP2 synthesis by the PIP5K isoforms was mediated by the RhoA effector, Rho kinase.
Stimulation of PIP5K isoforms by Rac1 and Cdc42 was apparently independent of and additive with RhoA- and Rho-kinase
RhoA, and to a lesser extent Rac1, but not Cdc42, interacted in a nucleotide-independent form with all three PIP5K isoforms.
Binding of PIP5K isoforms to GTP-bound, but not GDP-bound, RhoA could be displaced by Rho-kinase, suggesting a direct and constitutive PIP5K-Rho GTPase binding, which, however, does not trigger PIP5K activation.
Synthesis of PIP2 by the three PIP5K isoforms is controlled by RhoA, acting via Rho-kinase, as well as Rac1 and Cdc42, implicating that regulation of PIP2 synthesis has a central position in signaling by these three Rho GTPases.

Modifications:
In compartment: Cytosol
  1. Cytoskeleton remodeling@Cytosol map
In compartment: Nucleus
  1. Cytoskeleton remodeling@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. em_emtc_emtc_s2958 → map Cytoskeleton remodeling@Nucleus map
    2. RHOB:​RhoB_cytoskeletal_effectors*@Cytosol map → map Cytoskeleton remodeling@Nucleus map
    3. ARFIP2@Cytosol map → map Cytoskeleton remodeling@Nucleus map
    4. PIP5K1*@Cytosol map → map Cytoskeleton remodeling@Nucleus map
    5. Actin polymerization@Nucleus map → map Cytoskeleton remodeling@Nucleus map
    6. em_emtc_emtc_s3038 → map Cytoskeleton remodeling@Nucleus map
    7. Microtubule stability@Cytosol map → map Cytoskeleton remodeling@Nucleus map
    8. Cytoskeleton remodeling@Nucleus map → map Cell motility@Cytosol map
    9. Cytoskeleton remodeling@Nucleus map → map EMT@Cytosol map
    10. Actin cytoskeleton@Cytosol map → map Cytoskeleton remodeling@Cytosol map
    11. Actin polymerisation@Cytosol map → map Cytoskeleton remodeling@Cytosol map
    12. Actin fibers disassembly@Cytosol map → map Cytoskeleton remodeling@Cytosol map
    13. F-actin???rich membrane protrusions@Cytosol map → map Cytoskeleton remodeling@Cytosol map
    14. Actin remodeling@Cytosol map → map Cytoskeleton remodeling@Cytosol map
    15. Actin fibers disassembly@Nucleus map → map Cytoskeleton remodeling@Cytosol map
    16. microtubule fomation@Cytosol map → map Cytoskeleton remodeling@Cytosol map
    17. Intermediate filaments@Cytosol map → map Cytoskeleton remodeling@Cytosol map
    18. Intermediate filaments disasembly@Cytosol map → map Cytoskeleton remodeling@Cytosol map
    19. destabilizing microtubule@Cytosol map → map Cytoskeleton remodeling@Cytosol map
    20. Actin fibers*:​EZR|​Thr 567_pho@Cytosol map → map Cytoskeleton remodeling@Cytosol map
    As Catalyser: