Identifiers
NAME:RHOB:RhoB_cytoskeletal_effectors*
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CELL_CELL_ADHESIONS
EMT Senescence / TIGHT_JUNCTIONS
EMT Senescence / CYTOSKELETON_POLARITY
References
Once activated, the GTPases bind to a spectrum of effectors to stimulate downstream signaling pathways.
RhoB binding to DIAPH1, DIAPH2 and RHPN2 leads to actin polymerization and cytoskeleton rearrangements, and also regulates endosomal trafficking.
PRK1 and RTKN are also RhoB downstream effectors.
RhoB can directly bind to PLCE1 and stimulate its enzymatic activity.