Protein GPCR* map

Identifiers
G protein-coupled receptor 1
HUGO:GPR1 HGNC:4463 ENTREZ:2825 UNIPROT:P46091
G protein-coupled receptor 3
HUGO:GPR3 HGNC:4484 ENTREZ:2827 UNIPROT:P46089
G protein-coupled receptor 4
HUGO:GPR4 HGNC:4497 ENTREZ:2828 UNIPROT:P46093
G protein-coupled receptor 6
HUGO:GPR6 HGNC:4515 ENTREZ:2830 UNIPROT:P46095
G protein-coupled receptor 12
HUGO:GPR12 HGNC:4466 ENTREZ:2835 UNIPROT:P47775
G protein-coupled receptor 15
HUGO:GPR15 HGNC:4469 ENTREZ:2838 UNIPROT:P49685
G protein-coupled receptor 17
HUGO:GPR17 HGNC:4471 ENTREZ:2840 UNIPROT:Q13304
G protein-coupled receptor 18
HUGO:GPR18 HGNC:4472 ENTREZ:2841 UNIPROT:Q14330
G protein-coupled receptor 19
HUGO:GPR19 HGNC:4473 ENTREZ:2842 UNIPROT:Q15760
G protein-coupled receptor 20
HUGO:GPR20 HGNC:4475 ENTREZ:2843 UNIPROT:Q99678

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map

References
Phosphorylation of GPCR (by GRK) induces the activation of ERK cascade on eary endosomes.
PMID:19565474

GPCR*@Plasma Membrane

References
su_mpk1_mpk1_re85( Survival  map ):
Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN.
PMID:11226259

Modifications:
In compartment: Plasma Membrane
  1. GPCR*@Plasma Membrane map
Participates in complexes:
In compartment: Early Endosomes
  1. GPCR*:​GRK*@Early Endosomes map
  2. ERK*|​pho|​pho:​GPCR*:​GRK*:​MEK*|​pho|​pho:​RAF1|​pho:​_beta_-Arrestin2*@Early Endosomes map
In compartment: Plasma Membrane
  1. GPCR*|​pho:​GRK*@Plasma Membrane map
  2. GPCR*|​pho:​GRK*:​_beta_-Arrestin2*@Plasma Membrane map
Participates in reactions:
As Reactant or Product:
  1. GPCR*|​pho:​GRK*@Plasma Membrane map + _beta_-Arrestin2*@Cytoplasm map → map GPCR*|​pho:​GRK*:​_beta_-Arrestin2*@Plasma Membrane map
  2. GPCR*|​pho:​GRK*:​_beta_-Arrestin2*@Plasma Membrane map + ERK*@Cytoplasm map + RAF1@Cytoplasm map + MEK*@Cytoplasm map → map ERK*|​pho|​pho:​GPCR*:​GRK*:​MEK*|​pho|​pho:​RAF1|​pho:​_beta_-Arrestin2*@Early Endosomes map
  3. GPCR*@Plasma Membrane map + GRK*@Cytoplasm map → map GPCR*|​pho:​GRK*@Plasma Membrane map
  4. ERK*|​pho|​pho:​GPCR*:​GRK*:​MEK*|​pho|​pho:​RAF1|​pho:​_beta_-Arrestin2*@Early Endosomes map → map GPCR*:​GRK*@Early Endosomes map + ERK*|​pho|​pho:​MEK*|​pho|​pho:​_beta_-Arrestin2*@Early Endosomes map + RAF1@Cytoplasm map
As Catalyser: