Protein Claudin1* map

Identifiers
claudin 1
HUGO:CLDN1, HGNC:2032, ENTREZ:9076, UNIPROT:O95832, GENECARDS:GC03M190023

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / TIGHT_JUNCTIONS  map

Claudin1*@Cytosol

References
em_emtc_emtc_re590( EMT Senescence  map ):
PMID:15070779
WNK4 binds and phosphorylates claudins 1???4.
Claudins 1???4 are known to be involved in the regulation of paracellular ion permeability.
The increases in phosphorylation of claudins were greater in cells expressing the mutant WNK4 than in cells expressing wild-type protein.
Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins.
So the phosphorylation of Claudins 1-4 by WNK4 involves in the regulation of paracellular ion permeability

Modifications:
In compartment: Cytosol
  1. Claudin1*@Cytosol map
In compartment: Neighbouring Cell
  1. Claudin1*@Neighbouring Cell map
Participates in complexes:
In compartment: Neighbouring Cell
  1. Claudin1*:​Claudin3*@Neighbouring Cell map
  2. Claudin1*:​Occludin*@Neighbouring Cell map
Participates in reactions:
As Reactant or Product:
  1. Claudin1*@Neighbouring Cell map + Claudin1*@Cytosol map → map em_s2505
  2. Claudin1*@Neighbouring Cell map + Claudin3*@Cytosol map → map Claudin1*:​Claudin3*@Neighbouring Cell map
  3. Occludin*@Cytosol map + Claudin1*@Cytosol map → map Claudin1*:​Occludin*@Neighbouring Cell map
  4. rClaudin1*@Nucleus map → map Claudin1*@Cytosol map
  5. Occludin_Claudin1_2_4_5_7_8_16*@Cytosol map → map Claudin1*@Cytosol map
  6. Claudin1_5_8*@Cytosol map → map Claudin1*@Cytosol map
  7. Claudin1_2_3_4*@Cytosol map → map Claudin1*@Cytosol map
  8. Claudin1*:​Occludin*@Neighbouring Cell map → map Tight junctions@Neighbouring Cell map
  9. Claudin1*:​Claudin3*@Neighbouring Cell map → map Tight junctions@Neighbouring Cell map
As Catalyser: