Identifiers
HUGO:MIR21
microRNA 21
HUGO:MIR21, HGNC:31586, ENTREZ:406991, GENECARDS:GC17P057918

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts   / CORE 
 Cancer Associated Fibroblasts   / GROWTH_FACTORS_SIGNALING_PATHWAYS 
 EMT Senescence   / EMT_REGULATORS 

References
CASCADE:TGFB
PMID:23784029
mature??miR-21??increases after TGF-??1 treatment, whereas the??Smad??7??protein level decreases.??MiR-21??binds to the 3' UTR of Smad7 mRNA and inhibits its translation, rather than causing its degradation. Most importantly,??Smad??7??is bound to??Smad??2 and 3, which are thought to competitively bind to TGFBR1, and prevents their activation upon TGF-??1 stimulation. The depletion of??miR-21??or the overexpression of??Smad??7??blocks TGF-??1-induced??CAF??formation, whereas the overexpression of??miR-21??or the depletion of??Smad??7??promotes??CAF??formation, even without TGF-??1 stimulation.

References
mo_re193:( motility  ) PMID:22677902

1. gMIR21@Cytosol

1. gMIR21@Nucleus

1. gMIR21@Cytosol → arMIR21@Cytosol
2. gMIR21@Nucleus → arMIR21@Nucleus
3. gMIR21@Nucleus → arMIR21@Nucleus