Protein ITGAV map

Identifiers
integrin subunit alpha V
HUGO:ITGAV hgnc_id:HGNC:6150 HGNC:6150 ENTREZ:3685 UNIPROT:P06756
integrin, alpha V
"antigen identified by monoclonal antibody L230", "integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)", MSK8, "vitronectin receptor", VNRA, VTNR
HUGO:ITGAV HGNC:6150 ENTREZ:3685 UNIPROT:P06756 GENECARDS:GC02P187418
HUGO:ITGAV

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map
 EMT Senescence  map  / ECM  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / INTEGRINS  map
 Innate Immunity  map  / DANGER_SIGNAL_PATHWAYS  map

References
CASCADE:INTEGRIN
PMID:18353785
Transforming Growth Factor ??1 Induces ??v??3 Integrin Expression in Human Lung Fibroblasts via a ??3 Integrin-, c-Src-, and p38 MAPK-dependent Pathway*
 DENDRITIC_CELL  map
CASCADE:INTEGRIN_AVB5
CASCADE:INTEGRIN_AVB3
PMID:9295024, PMID:9763615
Dendritic cells phagocytose apoptotic cells via alphavbeta5, alphavbeta3, and CD36.
The interaction between apoptotic bodies and dendritic cells elicits a rise in intracellular free calcium concentration ([Ca2+]i) which is essential for the process of engulfment.

Modifications:
In compartment: Cytosol
  1. ITGAV@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. ITGAV:​ITGB3@Cytosol map
  2. FAK*:​ITGAV:​ITGB3@Cytosol map
In compartment: Extracellular space
  1. (ITGAV:​ITGB3)|​active@Extracellular space map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. ITGAV:​ITGB3@INNATE_IMMUNE_CELL_Membrane map
  2. ITGAV:​ITGB5@INNATE_IMMUNE_CELL_Membrane map
  3. ITGAV:​ITGB5:​MFGE8@INNATE_IMMUNE_CELL_Membrane map
  4. ITGAV:​ITGB3:​MFGE8:​PtdSer@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. ITGAV:​ITGB3@Cytosol map + FAK*@Cytosol map → map FAK*:​ITGAV:​ITGB3@Cytosol map
  2. ITGB3@Cytosol map + ITGAV@Cytosol map → map ca_s4773
  3. ITGAV@Cytosol map + ITGB5@Cytosol map → map ca_s4776
  4. ITGAV@Cytosol map + ITGB6@Cytosol map → map ca_s4779
  5. Collagen1 partners*@Extracellular space map → map ITGAV:​ITGB3@Cytosol map
  6. Talin partners*@Cytosol map → map ITGAV:​ITGB3@Cytosol map
  7. rITGAV@Nucleus map → map ITGAV@Cytosol map
  8. ITGAV@Cytosol map + ITGB8@Cytosol map → map em_emtc_emtc_s3144
  9. ITGAV@Cytosol map + ITGB6@Cytosol map → map em_emtc_emtc_s3141
  10. ITGAV@Cytosol map + ITGB5@Cytosol map → map em_emtc_emtc_s3138
  11. ITGAV@Cytosol map + ITGB1@Cytosol map → map em_emtc_emtc_s3132
  12. ITGAV@Cytosol map + ITGB3@Cytosol map → map ITGAV:​ITGB3@Cytosol map
  13. ITGAV:​ITGB3@Cytosol map → map ITGAV:​ITGB3@Cytosol map
  14. L1CAM@Cytosol map + ITGAV:​ITGB3@Cytosol map → map em_emtc_emtc_s3594
  15. ITGAV:​ITGB3@Cytosol map → map Angiogenesis@Nucleus map
  16. a5b1*_aVb3*@Extracellular space map → map ITGAV:​ITGB3@Cytosol map
  17. aVb3*_aVb5*@Extracellular space map → map ITGAV:​ITGB3@Cytosol map
  18. Fibronectin*:​a5b1*_aVb3*@Extracellular space map → map (ITGAV:​ITGB3)|​active@Extracellular space map
  19. PtdSer@TUMOR_CELL_AS_INDUCTOR_Membrane map + MFGE8@TUMOR_CELL_AS_INDUCTOR_Membrane map + ITGAV:​ITGB3@INNATE_IMMUNE_CELL_Membrane map → map ITGAV:​ITGB3:​MFGE8:​PtdSer@INNATE_IMMUNE_CELL_Membrane map
  20. ITGAV:​ITGB3:​MFGE8:​PtdSer@INNATE_IMMUNE_CELL_Membrane map → map EXOCYTOSIS_AND_PHAGOCYTOSIS@INNATE_IMMUNE_CELL_Membrane map
  21. ITGAV:​ITGB5@INNATE_IMMUNE_CELL_Membrane map + MFGE8@TUMOR_CELL_AS_INDUCTOR_Membrane map → map ITGAV:​ITGB5:​MFGE8@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. FAK1*|​emp@Cytosol map → map FAK1*|​pho@Cytosol map
  2. Tumor_antigen@TUMOR_CELL_AS_EFFECTOR map → map Tumor_antigen@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
  3. CRK@INNATE_IMMUNE_CELL_Cytosol map + DOCK1@INNATE_IMMUNE_CELL_Cytosol map + BCAR1@INNATE_IMMUNE_CELL_Cytosol map → map BCAR1:​CRK:​DOCK1@INNATE_IMMUNE_CELL_Cytosol map