Protein a5b1*_aVb3* map

Identifiers
a5b1*_aVb3*
NAME:a5b1*
ITGA5/ITGB1
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
HUGO:ITGA5, HGNC:6141, ENTREZ:3678, UNIPROT:P08648, GENECARDS:GC12M054789
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
HUGO:ITGB1, HGNC:6153, ENTREZ:3688, UNIPROT:P05556, GENECARDS:GC10M033189
NAME:aVb3*
ITGAV/ITGB3
integrin, alpha V
"antigen identified by monoclonal antibody L230", "integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)", MSK8, "vitronectin receptor", VNRA, VTNR
HUGO:ITGAV HGNC:6150 ENTREZ:3685 UNIPROT:P06756 GENECARDS:GC02P187418
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
GP3A
HUGO:ITGB3 HGNC:6156 ENTREZ:3690 UNIPROT:P05106 GENECARDS:GC17P045331

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map

References
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
PMID:19487819
During gastrulation, type 1 EMT is associated with de novo expression of a5b1, which is a receptor for fibronectin.
Type 2 EMT in experimental kidney fibrosis is associated with increased a5 integrin expression.

a5b1*_aVb3*@Extracellular space

References
em_emtc_emtc_re909( EMT Senescence  map ):
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
Integrins a1b1, a2b1, a10b1 and a11b1 bind to collagens
PMID:12297042
Cell adhesion to components of the ECM is important in the angiogenesis
PMID:2153105
PMID:2786007
PMID:7639691
PMID:10809728
integrins are receptors for different ECM proteins: Collagen 1, 4; Laminin 1, 8; Fibronectin and Vitronectin
PMID:7522194
PMID:16195317
Interactions between integrins and the ECM proteins result in focal cell adhesion and cytoskeleton remodeling.
PMID:15866889
Fibronectin binds to alphaV/beta3 integrins supports persistent migration( directional cell migration)
Fibronectin binds to alpha5/beta1 integrins supports random migration.

Modifications:
In compartment: Extracellular space
  1. a5b1*_aVb3*@Extracellular space map
Participates in complexes:
In compartment: Extracellular space
  1. Fibronectin*:​a5b1*_aVb3*@Extracellular space map
Participates in reactions:
As Reactant or Product:
  1. Fibronectin partners*@Extracellular space map → map a5b1*_aVb3*@Extracellular space map
  2. Fibronectin*@Extracellular space map + a5b1*_aVb3*@Extracellular space map → map Fibronectin*:​a5b1*_aVb3*@Extracellular space map
  3. a5b1*_aVb3*@Extracellular space map → map ITGA5:​ITGB1@Cytosol map
  4. a5b1*_aVb3*@Extracellular space map → map ITGAV:​ITGB3@Cytosol map
  5. Fibronectin*:​a5b1*_aVb3*@Extracellular space map → map (ITGA5:​ITGB1)|​active@Extracellular space map
  6. Fibronectin*:​a5b1*_aVb3*@Extracellular space map → map (ITGAV:​ITGB3)|​active@Extracellular space map
  7. Fibronectin*:​a5b1*_aVb3*@Extracellular space map → map Cell-matrix adhesions@Extracellular space map
As Catalyser: