Identifiers
a1b1*_a2b1*
a1b1*
ITGA1/ITGB1
integrin, alpha 1
HUGO:ITGA1 HGNC:6134 ENTREZ:3672 UNIPROT:P56199
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
HUGO:ITGB1, HGNC:6153, ENTREZ:3688, UNIPROT:P05556, GENECARDS:GC10M033189
a2b1*
ITGA2/ITGB1
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
CD49B
HUGO:ITGA2 HGNC:6137 ENTREZ:3673 UNIPROT:P17301
aVb3*
ITGAV/ITGB3
integrin, alpha V
"antigen identified by monoclonal antibody L230", "integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)", MSK8, "vitronectin receptor", VNRA, VTNR
HUGO:ITGAV HGNC:6150 ENTREZ:3685 UNIPROT:P06756 GENECARDS:GC02P187418
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
GP3A
HUGO:ITGB3 HGNC:6156 ENTREZ:3690 UNIPROT:P05106 GENECARDS:GC17P045331
fibronectin 1
HUGO:FN1, HGNC:3778, ENTREZ:2335, UNIPROT:P02751, GENECARDS:GC02M216225
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / ECM
EMT Senescence / CELL_MATRIX_ADHESIONS
References
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
Integrins a1b1, a2b1, a10b1 and a11b1 bind to collagens
→ ITGAV:ITGB3@Cytosol
→ a1b1*_a2b1*@Extracellular space
→ Fibronectin*@Extracellular space
+ Collagen1 partners*@Extracellular space → Collagen1 partners*:Collagen1*@Extracellular space
→ Cell-matrix adhesions@Extracellular space