Protein HGF map

Identifiers
HGNC:4893
hepatocyte growth factor
HUGO:HGF hgnc_id:HGNC:4893 HGNC:4893 ENTREZ:3082 UNIPROT:P14210
hepatocyte growth factor (hepapoietin A; scatter factor)
HUGO:HGF HGNC:4893 ENTREZ:3082 UNIPROT:P14210
HUGO:HGF

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_SIGNALING_PATHWAYS  map
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_PRODUCTION  map
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map
 Innate Immunity  map  / TUMOR_GROWTH  map

References
PMID:17145802 PMID:26366398
CASCADE:IL1
CASCADE:FGF
CASCADE:PDGF
CASCADE:HGF
PMID:9242465; PMID:19631971
IL1B, FGF2, FGF1, FGF4, PDGF induce HGF expression and production in fibroblasts
PMID:27474009
HGF is a activation factor for fibroblasts
PMID:23667593
Cancer-Associated Fibroblasts from Hepatocellular Carcinoma Promote Malignant Cell Proliferation by HGF Secretion
PMID:23402812
Hepatocyte growth factor activates tumor stromal fibroblasts to promote tumorigenesis in gastric cancer.
HGF induces expression markers of activated fibroblasts such as FAP, CXCL12 (SDF1),aplpha-SMA
PMID:15059978
Proinvasive factors secreted by myofibroblasts are identified as TNC and SF/HGF, each of
which is necessary but not sufficient for stimulation of invasion of human colon cancer cells
PMID:22763439
HGF is present in the stromal cells of melanoma and correlates with poor response to therapy
 MACROPHAGE  map
 NEUTROPHIL  map
PMID:18633355
Hypoxia induces a distinct pro-angiogenic phenotype in human macrophages in vitro42, 43 including the upregulation of VEGF, bFGF, CXCL8, COX2, hepatocyte growth factor (HGF), VEGFR1, tissue factor (F3) and MMP12.
PMID:16212809
HGF drives tumor growth
PMID:26819959, PMID:12649206
Neutrophiles produce HGF and induce tumor growth
High HGF levels in BALF supernatants were significantly associated with poorer outcome in patients with BAC
PMID:28475121

Modifications:
In compartment: Cytosol
  1. HGF@Cytosol map
In compartment: Extracellular Matrix
  1. HGF@Extracellular Matrix map
In compartment: Extracellular space
  1. HGF@Extracellular space map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. HGF@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Membrane
  1. HGF@Membrane map
In compartment: default
  1. HGF@default map
Participates in complexes:
In compartment: Cytosol
  1. HGF:​MET@Cytosol map
In compartment: Membrane
  1. HGF:​MET|​pho@Membrane map
Participates in reactions:
As Reactant or Product:
  1. MET@Cytosol map + HGF@Extracellular Matrix map → map HGF:​MET@Cytosol map
  2. HGF:​MET@Cytosol map → map Lymphangiogenesis@Cytosol map
  3. HGF@Cytosol map → map GROWTH_FACTORS_PRODUCTION@default map
  4. HGF@Cytosol map → map HGF@default map
  5. rHGF@Cytosol map → map HGF@Cytosol map
  6. HGF@default map + MET@Cytosol map → map ca_s4530
  7. HGF@Extracellular space map + c-MET*@Cytosol map + c-MET*@Cytosol map → map em_emtc_emtc_s4814
  8. HGF@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
  9. HGF@INNATE_IMMUNE_CELL_Cytosol map → map TUMOR_GROWTH@TUMOR_CELL_AS_EFFECTOR map
  10. HGF@Membrane map + MET@Membrane map → map HGF:​MET|​pho@Membrane map
  11. HGF:​MET|​pho@Membrane map → map PLCG_PATHWAYS@Membrane map
  12. HGF:​MET|​pho@Membrane map → map PI3K_PATHWAY@Membrane map
  13. HGF:​MET|​pho@Membrane map → map JAK/STAT_PATHWAY@Membrane map
  14. HGF:​MET|​pho@Membrane map → map MAPK_PATHWAYS@Membrane map
As Catalyser:
  1. gFAP@Cytosol map → map rFAP@Cytosol map
  2. gCXCL12@Cytosol map → map rCXCL12@Cytosol map
  3. gACTA2@Cytosol map → map rACTA2@Cytosol map