Protein MET map

Identifiers
HGNC:7029
MET proto-oncogene, receptor tyrosine kinase
HUGO:MET hgnc_id:HGNC:7029 HGNC:7029 ENTREZ:4233 UNIPROT:P08581
HUGO:MET

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_SIGNALING_PATHWAYS  map

References
PMID:17145802
PMID:11290563
Human myofibroblasts derived from primary lung cancer expressed c-MET mRNA and protein
Proliferation of myofibroblasts was stimulated in a dose-dependent manner by exogenously added recombinant human HGF whereas it was inhibited in a dose-dependent manner by neutralizing antibody to HGF. The addition of HGF in the culture medium stimulated tyrosine phosphorylation of c-MET.
A significant relationship between myofibroblast c-MET expression and shortened patient survival was observed.
PMID:28475121 PMID:20303741

Modifications:
In compartment: Cytosol
  1. MET@Cytosol map
In compartment: Membrane
  1. MET@Membrane map
Participates in complexes:
In compartment: Cytosol
  1. HGF:​MET@Cytosol map
In compartment: Membrane
  1. HGF:​MET|​pho@Membrane map
Participates in reactions:
As Reactant or Product:
  1. MET@Cytosol map + HGF@Extracellular Matrix map → map HGF:​MET@Cytosol map
  2. HGF:​MET@Cytosol map → map Lymphangiogenesis@Cytosol map
  3. HGF@default map + MET@Cytosol map → map ca_s4530
  4. HGF@Membrane map + MET@Membrane map → map HGF:​MET|​pho@Membrane map
  5. HGF:​MET|​pho@Membrane map → map PLCG_PATHWAYS@Membrane map
  6. HGF:​MET|​pho@Membrane map → map PI3K_PATHWAY@Membrane map
  7. HGF:​MET|​pho@Membrane map → map JAK/STAT_PATHWAY@Membrane map
  8. HGF:​MET|​pho@Membrane map → map MAPK_PATHWAYS@Membrane map
As Catalyser: