Identifiers
BCL2/adenovirus E1B 19kDa interacting protein 2
"BCL2/adenovirus E1B 19kD-interacting protein 2"
HUGO:BNIP2 HGNC:1083 ENTREZ:663 UNIPROT:Q12982
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CYTOSKELETON_POLARITY
References
PMID:10551883
FGFR1 regulates activity of CDC42 by binding and phosphorylating thus inactivating BCL2.
Phosphorylated BCL2 binds to another CDC42_GAP, ARHGAP1 and neutralize the GAP activity of ARHGAP1 as well.
References
em_emtc_emtc_re883( EMT Senescence ):
PMID:10551883
FGFR1 regulates activity of CDC42 by binding and phosphorylating thus inactivating BCL2.
Phosphorylated BCL2 binds to another CDC42_GAP, ARHGAP1 and neutralize the GAP activity of ARHGAP1 as well.
em_emtc_emtc_re802( EMT Senescence ):
Rac1 stimulates actin polymerization by activation of WAS protein family (WASF1 and WASF2)
PMID:16212495
PMID:9843499
PMID:16702231
PMID:12181570
Rac1 binds to NCKAP1 and CYFIP2 and also promotes NCK1 binding to NCKAP1.
This binding inhibits NCKAP1 and CYFIP2 binding to WASF1 and promotes release of the complex of WASF1 and BRK1, thus activating WASF1.
Activated WASF1 then stimulates ARP2/3 that mediates actin cytoskeletal polymerizatioin
References
em_emtc_emtc_re894( EMT Senescence ):
PMID:10551883
FGFR1 regulates activity of CDC42 by binding and phosphorylating thus inactivating BCL2.
Phosphorylated BCL2 binds to another CDC42_GAP, ARHGAP1 and neutralize the GAP activity of ARHGAP1 as well.