Protein RhoB_GEFs* map

Identifiers
RhoB_GEFs*
Rho/Rac guanine nucleotide exchange factor (GEF) 2
HUGO:ARHGEF2, HGNC:682, ENTREZ:9181, GENECARDS:GC01M155916, UNIPROT:Q92974
Rho guanine nucleotide exchange factor (GEF) 3
HUGO:ARHGEF3, HGNC:683, ENTREZ:50650, GENECARDS:GC03M056736, UNIPROT:Q9NR81
Rho guanine nucleotide exchange factor (GEF) 10-like
HUGO:ARHGEF10L, HGNC:25540, ENTREZ:55160, GENECARDS:GC01P017866, UNIPROT:Q9HCE6

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

RhoB_GEFs*@Cytosol

References
em_emtc_emtc_re727( EMT Senescence  map ):
PMID:9857026
GEF-H1 is so-called ARHGEF2
GEFH1, which associates with tubulin in a manner dependent on a Zn-finger motif, is a regulator of the Rho family
GEFH1 is known to activate Rho A, B, C, and Rac1 but is inactive toward Cdc42, TC10, or Ras.
GEFH1 may have a direct role in activation of Rac and/or Rho and in bringing the activated GTPase to specific target sites such as microtubules.
PMID:16917499
The activation of GEFH1- RhoB through the TRIF-dependent pathway of LPS in DC might be a critical target for controlling the activation of CD4+ T cells.
PMID:12221096
XPLN (so-called ARHGEF3) is a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.
PMID:16112081
In vitro, GrinchGEF (ARHGEF10L) induced the GDP/ GTP exchange at RhoA, but not at Rac1 or Cdc42.
In intact cells, GrinchGEF induced specifically Rho activation and enhanced RhoA,B,C-specific downstream effect.
GrinchGEF, similar to its relative p164-RhoGEF (ARHGEF17), is a Rho-specific GEF.
Although RhoA, B, and C have different cellular functions, and some regulators and effectors show preferential interaction with these Rho isoforms, GrinchGEF apparently does not distinguish between RhoA,B,C and similarly activates these Rho proteins
PMID:9822605
Phosphorylated Vav-2 was found to be active on RhoA, RhoB and the more distantly related RhoG protein

Modifications:
In compartment: Cytosol
  1. RhoB_GEFs*@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. RhoB_GEFs*@Cytosol map → map ARHGEF2@Cytosol map
    2. RhoB_GEFs*@Cytosol map → map ARHGEF3@Cytosol map
    3. RhoB_GEFs*@Cytosol map → map ARHGEF10L@Cytosol map
    4. RhoB_GEFs*@Cytosol map → map VAV2@Cytosol map
    As Catalyser:
    1. em_emtc_emtc_s2943 → map em_emtc_emtc_s2942