Identifiers
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
HUGO:HUWE1 HGNC:30892 ENTREZ:10075 UNIPROT:Q7Z6Z7
HUGO:HUWE1 HGNC:30892 ENTREZ:10075 UNIPROT:Q7Z6Z7 GENECARDS:HUWE1 REACTOME:155590 KEGG:10075 ATLASONC:GC_HUWE1 WIKI:HUWE1
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / DNA_DAMAGE_RESPONSE
Regulated Cell Death / MOMP_REGULATION
Regulated Cell Death / RCD_GENES
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / WNT_NON_CANONICAL
References
synonym:MULE
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / DNA_DAMAGE_RESPONSE
Regulated Cell Death / MOMP_REGULATION
Regulated Cell Death / RCD_GENES
References
rc_re41( Regulated Cell Death ):
PMID:15989957
in Hela MCL1 ubiquitination mainly on lysines 136, 194, and 197
purification of MCL1 E3 ubiquitin ligase from the cytosol of Hela cells
in vitro reconstitution of the system
HUWE1 KD
PMID:16543145
suggest that HUWE1 preferentially target S159 phosphorylated MCL1 for polyubiquitination
PMID:16213503
HUWE1 is a BH3 domain protein - competition HUWE1 / Bim for binding to MCL1
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / DNA_DAMAGE_RESPONSE
Regulated Cell Death / MOMP_REGULATION
Regulated Cell Death / RCD_GENES
References
rc_re457:( Regulated Cell Death ) PMID:15989956
rc_re1127( Regulated Cell Death ):
PMID:19590512
Siva1 and mdm2
PMID:15989956
HUWE1
PMID:19960022
effect of SIRT1 K382-deacetylation