Gene BRCA1 map

Identifiers
breast cancer 1, early onset
HUGO:BRCA1, HGNC:1100, ENTREZ:672

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair  map  / G1_S_CHECKPOINT  map
 Cell Cycle DNA Repair  map  / S_PHASE_CHECKPOINT  map
 Cell Cycle DNA Repair  map  / G2_M_CHECKPOINT  map
 Cell Cycle DNA Repair  map  / HR  map
 Cell Cycle DNA Repair  map  / FANCONI  map

References
For S-phase checkpoint
PMID:11877377, PMID:15459660, PMID:19793801, PMID:20029420, PMID:21337561, PMID:21060331

gBRCA1@Nucleus

References
ce_re232( Cell Cycle DNA Repair  map ):
p53 inhibits BRCA1 expression, this is a negative loop as response to the up-regulation and stabilization of p53 by BRCA1:
PMID:10884389, PMID:12496474
BRIT1*/E2F1 complex activates BRCA1 and CHEK1 transcription during S-phase and G2/M checkpoints:
PMID:15220350, PMID:18660752

Modifications:
In compartment: Nucleus
  1. gBRCA1@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gBRCA1@Nucleus map → map rBRCA1@Nucleus map
    As Catalyser: