Protein SDHA map

Identifiers
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
HUGO:SDHA HGNC:10680 ENTREZ:6389 UNIPROT:P31040

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map
 RECON2  map

References
FAD cofactor binding

SDHA@Mitochondrial inner membrane

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map

References
rc_re64( Regulated Cell Death  map ):
PMID:19628817
SDH5 is required for SDHA flavination (inferred from yeast)
SDH5 primarily soluble and localized in mitochondrial matrix (inferred from yeast)
SDH5 mutation segregates with disease in a family with paraganglioma

Modifications:
In compartment: Mitochondrial inner membrane
  1. SDHA@Mitochondrial inner membrane map
Participates in complexes:
In compartment: Mitochondrial inner membrane
  1. FAD:​SDHA@Mitochondrial inner membrane map
  2. FAD:​SDHA:​SDHB|​[2Fe-2S],[4Fe-4S],[3Fe-4S]:​SDHC:​SDHD:​cardiolipin:​heme b:​phosphatidylethanolamine@Mitochondrial inner membrane map
Participates in reactions:
As Reactant or Product:
  1. SDHA@Mitochondrial inner membrane map + FAD@Mitochondrial inner membrane map → map FAD:​SDHA@Mitochondrial inner membrane map
  2. degraded + FAD:​SDHA@Mitochondrial inner membrane map + SDHB@Mitochondrial inner membrane map + SDHC@Mitochondrial inner membrane map + SDHD@Mitochondrial inner membrane map → map FAD:​SDHA:​SDHB|​[2Fe-2S],[4Fe-4S],[3Fe-4S]:​SDHC:​SDHD:​cardiolipin:​heme b:​phosphatidylethanolamine@Mitochondrial inner membrane map
As Catalyser:
  1. succinate@Mitochondrial Matrix map + ubiquinone@Mitochondrial inner membrane map → map fumarate@Mitochondrial Matrix map + ubiquinol@Mitochondrial inner membrane map