Simple molecule fumarate
fumarate@Cytosol
Identifiers
CHEBI:37154
References
rc_re387( Regulated Cell Death
):
PMID:12351678
identification of PHD2 as a HIF1A prolyl hydroxylase
PMID:15652751
inhibition of HIF1A prolyl hydroxylation by succinate and fumarate
PMID:15721254
in 293 cells, OS9 interacts with HIF1 and PHD and promotes HIF1A prolylhydroxylation and degradation
fumarate@Mitochondrial Matrix
Identifiers
CHEBI:29806 KEGGCOMPOUND:C00122 CAS:142-42-7
Modifications:
In compartment: Cytosol
- fumarate@Cytosol
In compartment: Mitochondrial Matrix
- fumarate@Mitochondrial Matrix
Participates in complexes:
Participates in reactions:
As Reactant or Product:- succinate@Mitochondrial Matrix
+ ubiquinone@Mitochondrial inner membrane
→
fumarate@Mitochondrial Matrix
+ ubiquinol@Mitochondrial inner membrane
- fumarate@Mitochondrial Matrix
→
malate@Mitochondrial Matrix
As Catalyser:- HIF1A@Cytosol
+ 2-oxoglutarate:CUL2:O_sub_2_endsub_:RACK1*:RBX1:TCEB1:TCEB2:VHL@Cytosol
+ 2-oxoglutarate:CUL2:O_sub_2_endsub_:RACK1*:RBX1:TCEB1:TCEB2:VHL@Cytosol
→
HIF1A|P564_hyd@Cytosol
+ succinate@Cytosol
+ CO_sub_2_endsub_@Cytosol