Complex FAD:SDHA
Complex composition:
- SDHA
- FAD
FAD:SDHA@Mitochondrial inner membrane
Identifiers
NAME:FAD:SDHA
Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death
/ ANTIOXIDANT_RESPONSE
Regulated Cell Death
/ MITOCHONDRIAL_METABOLISM
Regulated Cell Death
/ OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE
References
rc_re64( Regulated Cell Death
):
PMID:19628817
SDH5 is required for SDHA flavination (inferred from yeast)
SDH5 primarily soluble and localized in mitochondrial matrix (inferred from yeast)
SDH5 mutation segregates with disease in a family with paraganglioma
rc_re65:( Regulated Cell Death
) PMID:19465911
Modifications:
Participates in complexes:
In compartment: Mitochondrial inner membrane
- FAD:SDHA@Mitochondrial inner membrane
Participates in reactions:
As Reactant or Product:- SDHA@Mitochondrial inner membrane
+ FAD@Mitochondrial inner membrane
→
FAD:SDHA@Mitochondrial inner membrane
- degraded + FAD:SDHA@Mitochondrial inner membrane
+ SDHB@Mitochondrial inner membrane
+ SDHC@Mitochondrial inner membrane
+ SDHD@Mitochondrial inner membrane
→
FAD:SDHA:SDHB|[2Fe-2S],[4Fe-4S],[3Fe-4S]:SDHC:SDHD:cardiolipin:heme b:phosphatidylethanolamine@Mitochondrial inner membrane
As Catalyser: