Simple molecule NO map
NO@Cytosol

Identifiers

Maps_Modules

References

NO@default

Identifiers

Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC

References
PMID:21680779, PMID:22816309
Myeloid-derived suppressor cell inhibit the IFN response in immune cells (splenocytes) via inhibition of STAT1 phosphorylation by NO (downstream of iNOS).
But probably it doesn't work for macrophages where inhibition of INOS reduces STAT1 phosphorylation.

Modifications:
In compartment: Cytosol
  1. NO@Cytosol map
In compartment: default
  1. NO@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. L-arginine@Cytosol map + O_sub_2_endsub_@Cytosol map + NADPH@Cytosol map → map NO@Cytosol map + L-citrulin@Cytosol map + NADP+@Cytosol map
    2. NO@Cytosol map → map NO production@Cytosol map
    3. NO@Cytosol map → map NO@default map
    As Catalyser: