Protein IL6 map

Identifiers
HUGO:IL6

Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
PMID:20093776
IL6 signaling ilduces STAT3 phosphorylation in MDSC cells.
PMID:9716487
Interleukin-6-type cytokine signalling acts through the gp130/Jak/STAT pathway.
PMID:18977329
IL-1?? activates MDSC in vitro and in vivo through an IL-1RI/NF-??B pathway.
mRNA expression of several NF-??B target genes such is IL6, IL1B,TNF are IL1B/NFkB dependent in MSDC
PMID:17942936
IL-6 is a downstream mediator of the IL-1beta-induced expansion of MDSC

IL6@Cytosol

Identifiers

Maps_Modules

References

IL6@default

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. IL6@Cytosol map
In compartment: default
  1. IL6@default map
Participates in complexes:
In compartment: Membrane
  1. IL6:​IL6R:​gp130*|​Y759_pho@Membrane map
Participates in reactions:
As Reactant or Product:
  1. rIL6@Cytosol map → map IL6@Cytosol map
  2. IL6@Cytosol map → map IL6@default map
  3. IL6@default map + IL6R:​gp130*|​Y759_pho@Membrane map → map IL6:​IL6R:​gp130*|​Y759_pho@Membrane map
As Catalyser:
  1. TNF@Cytosol map → map TNF@default map
  2. STAT3@Cytosol map → map STAT3|​pho|​active@Cytosol map
  3. IL12p40*@Cytosol map → map IL12p40*@default map