Protein IL12p40* map

Identifiers
HUGO:IL12B

Maps_Modules
MODULE:MACROPHAGE
MODULE:IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION

References
PMID:16243976
IRF4 downregulates expression of TNFa, IL12p40, IL6 probably via inhibition of NF-kB and JNK signaling pathways.
PMID:12417340
IRF-8/ICSBP and IRF-1 cooperatively stimulate mouse IL-12 p40 promoter activity in macrophages.
IRF-1 can be acetylated by p300. p300 is recruited to the IL-12p40 promoter depending on both ICSBP and IRF-1
and acts as coactivator.

IL12p40*@Cytosol

Identifiers

Maps_Modules

References

IL12p40*@default

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. IL12p40*@Cytosol map
In compartment: default
  1. IL12p40*@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rIL12p40*@Cytosol map → map IL12p40*@Cytosol map
    2. IL12p40*@Cytosol map → map IL12p40*@default map
    3. IL12p40*@default map → map Proinflammatory chemokines and cytokines@default map
    As Catalyser: