Protein gp130* map

Identifiers
HUGO:IL6ST

Maps_Modules
MODULE:MACROPHAGE
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
PMID:12754507, PMID:24418198
SOCS3 binds with high affinity to the phosphorylated Tyr759 (Y759)
Of gp130 to suppress IL-6 signaling.

Modifications:
Participates in complexes:
In compartment: Membrane
  1. IL6R:​gp130*|​Y759_pho@Membrane map
  2. IL6:​IL6R:​gp130*|​Y759_pho@Membrane map
  3. IL6R:​SOCS3:​gp130*|​Y759_pho@Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL6R:​gp130*|​Y759_pho@Membrane map + SOCS3@Cytosol map → map IL6R:​SOCS3:​gp130*|​Y759_pho@Membrane map
  2. IL6@default map + IL6R:​gp130*|​Y759_pho@Membrane map → map IL6:​IL6R:​gp130*|​Y759_pho@Membrane map
As Catalyser:
  1. TNF@Cytosol map → map TNF@default map
  2. STAT3@Cytosol map → map STAT3|​pho|​active@Cytosol map
  3. IL12p40*@Cytosol map → map IL12p40*@default map