Complex S100A8:S100A9
Complex composition:
- S100A8
- S100A9
S100A8:S100A9@Cytosol
PMID:18802069, PMID:23248262
MDSC synthesize and secrete S100A8/A9 heterodimers
PMID: 25614008
The S100A8???S100A9 heterodimer has been documented to have physiologically relevant functions in vivo
Modifications:
Participates in complexes:
In compartment: Cytosol
- S100A8:S100A9@Cytosol
In compartment: default
- S100A8:S100A9@default
Participates in reactions:
As Reactant or Product:- S100A9@Cytosol
+ S100A8@Cytosol
→
S100A8:S100A9@Cytosol
- S100A8:S100A9@Cytosol
→
S100A8:S100A9@default
- RAGE*@Membrane
+ S100A8:S100A9@default
→
RAGE*:S100A8:S100A9@Membrane
As Catalyser:- GTP:RAC1_2*@Cytosol
+ NCF2@Cytosol
+ NCF4@Cytosol
+ CYBA@Cytosol
+ NCF1@Cytosol
+ CYBB@Cytosol
+ FAD@Cytosol
+ heme@Cytosol
→
CYBA:CYBB:FAD:GTP:NCF1:NCF2:NCF4:RAC1_2*:heme@Cytosol