Protein CYBB map
HUGO:CYBB
MODULE:MDSC
MODULE:NO_ROS_PRODUCTION
PMID:19372727
The enzyme responsible for O2???- production is called the NADPH oxidase or respiratory burst oxidase. This multicomponent enzyme system is composed of two transmembrane proteins (p22phox and gp91phox, also called NOX2, which together form the cytochrome b558) and four cytosolic proteins (p47phox, p67phox, p40phox and a GTPase Rac1 or Rac2), which assemble at membrane sites upon cell activation.
PMID:19380816, PMID:21383238
The increased ROS production by MDSC is mediated by up-regulated activity of NADPH oxidase (NOX2).
STAT3 upregulates expression of NOX2 subunits, primarily p47(NCF1) and gp91(CYBB) in MDSC,
In the absence of NOX2 activity, MDSC lost the ability to suppress T cell responses and quickly differentiated into mature macrophages and dendritic cells.
Modifications:
In compartment: Cytosol
  1. CYBB@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. CYBA:​CYBB:​FAD:​GTP:​NCF1:​NCF2:​NCF4:​RAC1_2*:​heme@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. GTP:​RAC1_2*@Cytosol map + NCF2@Cytosol map + NCF4@Cytosol map + CYBA@Cytosol map + NCF1@Cytosol map + CYBB@Cytosol map + FAD@Cytosol map + heme@Cytosol map → map CYBA:​CYBB:​FAD:​GTP:​NCF1:​NCF2:​NCF4:​RAC1_2*:​heme@Cytosol map
  2. rCYBB@Cytosol map → map CYBB@Cytosol map
As Catalyser:
  1. O_sub_2_endsub_@Cytosol map → map O_sub_2_endsub__super_-_endsuper_@Cytosol map