Protein S100A9
MODULE:MDSC
MODULE:RECRUITMENT_OF_IMMUNE_CELLS
HUGO:S100A9
HUGO:S100A9
PMID:18802069, PMID:23248262
S100A8/A9 proteins are chemotactic for MDSC.
S100A8/A9 proteins bind to carboxylated N-glycans expressed on the receptor (probably RAGE) for advanced glycation end-products and other cell surface glycoprotein receptors on MDSC, signal through the NF-kappaB pathway, and promote MDSC migration and immunosuppressive function.
PMID:18809714, PMID:12645005
S100A9 regulates myeloid cell differentiation via reactive oxygen species (ROS), probabli via NAPDH oxidase.
S100A9 may suppress myeloid cell differentiation via persistent up-regulation of ROS in progenitor cells.

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Modifications:
In compartment: Cytosol

1. S100A9@Cytosol

Participates in complexes:
In compartment: Cytosol

1. S100A8:​S100A9@Cytosol

In compartment: Membrane

1. RAGE*:​S100A8:​S100A9@Membrane

In compartment: default

1. S100A8:​S100A9@default

Participates in reactions:
As Reactant or Product:

1. S100A9@Cytosol + S100A8@Cytosol → S100A8:​S100A9@Cytosol
2. S100A8:​S100A9@Cytosol → S100A8:​S100A9@default
3. RAGE*:​S100A8:​S100A9@Membrane → Migration into tumor@default
4. RAGE*@Membrane + S100A8:​S100A9@default → RAGE*:​S100A8:​S100A9@Membrane

As Catalyser:

1. NFKB1_p50*:​NFKBIA:​RELA@Cytosol → NFKB1_p50*:​NFKBIA|​pho:​RELA|​pho@Cytosol
2. GTP:​RAC1_2*@Cytosol + NCF2@Cytosol + NCF4@Cytosol + CYBA@Cytosol + NCF1@Cytosol + CYBB@Cytosol + FAD@Cytosol + heme@Cytosol → CYBA:​CYBB:​FAD:​GTP:​NCF1:​NCF2:​NCF4:​RAC1_2*:​heme@Cytosol