Protein RAGE* map
HUGO:AGER
MODULE:MDSC
MODULE:RECRUITMENT_OF_IMMUNE_CELLS
PMID:18802069, PMID:23248262
S100A8/A9. S100A8/A9 proteins bind to carboxylated N-glycans expressed on the receptor (probably RAGE) for advanced glycation end-products and other cell surface glycoprotein receptors on MDSC, signal through the NF-kappaB pathway, and promote MDSC migration and immunosuppressive function..
Modifications:
In compartment: Membrane
  1. RAGE*@Membrane map
Participates in complexes:
In compartment: Membrane
  1. RAGE*:​S100A8:​S100A9@Membrane map
Participates in reactions:
As Reactant or Product:
  1. RAGE*:​S100A8:​S100A9@Membrane map → map Migration into tumor@default map
  2. RAGE*@Membrane map + S100A8:​S100A9@default map → map RAGE*:​S100A8:​S100A9@Membrane map
As Catalyser:
  1. NFKB1_p50*:​NFKBIA:​RELA@Cytosol map → map NFKB1_p50*:​NFKBIA|​pho:​RELA|​pho@Cytosol map