Protein trILB1
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
PMID:19104081
Inflammasome is needfull for processing and release of IL-1beta in monocytes downstream of TLR2 or TLR4 signaling.
It contains CASP1, Pycard, NLRP3 (NALP3)
PMID: 23202296
(Nlrp3)-dependent caspase-1 activation complex (termed the inflammasome) in myeloid-derived suppressor cells (MDSCs), leading to production of interleukin-1?? (IL-1??), which curtails anticancer immunity.
PMID: 24727385
Tumor-derived IL-1?? secreted into the tumor microenvironment has been shown to induce the accumulation of MDSC that promotes tumor growth.
PMID:18977329
IL-1?? activates MDSC in vitro and in vivo through an IL-1RI/NF-??B pathway.
mRNA expression of several NF-??B target genes such is IL6, IL1B,TNF are IL1B/NFkB dependent in MSDC
PMID:17942936
IL-1R???deficient mice have a delayed accumulation of MDSC and reduced primary and metastatic tumor progression. Accumulation of MDSC and tumor progression are partially restored by IL-6, indicating that IL-6 is a downstream mediator of the IL-1?????induced expansion of MDSC. IL-1Ra (IL-1R antagonis) ???/??? MDSC are more suppressive than BALB/c MDSC.

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Modifications:
In compartment: Cytosol

1. trILB1@Cytosol

In compartment: default

1. trILB1@default

Participates in complexes:
In compartment: Membrane

1. IL1R1:​IL1RAP:​trILB1@Membrane

Participates in reactions:
As Reactant or Product:

1. IL1R1:​IL1RAP:​trILB1@Membrane → Migration into tumor@default
2. trILB1@default + IL1R1:​IL1RAP@Membrane → IL1R1:​IL1RAP:​trILB1@Membrane
3. IL1B@Cytosol → trILB1@Cytosol
4. trILB1@Cytosol → trILB1@default

As Catalyser:

1. rRELA@Cytosol → RELA@Cytosol