Protein IL1B map

Identifiers
HUGO:IL1B

Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
PMID: 24727385
Tumor-derived IL-1?? secreted into the tumor microenvironment has been shown to induce the accumulation of MDSC that promotes tumor growth.
PMID:18977329
IL-1?? activates MDSC in vitro and in vivo through an IL-1RI/NF-??B pathway.
mRNA expression of several NF-??B target genes such is IL6, IL1B,TNF are IL1B/NFkB dependent in MSDC
PMID:17942936
IL-1R???deficient mice have a delayed accumulation of MDSC and reduced primary and metastatic tumor progression. Accumulation of MDSC and tumor progression are partially restored by IL-6, indicating that IL-6 is a downstream mediator of the IL-1?????induced expansion of MDSC. IL-1Ra (IL-1R antagonis) ???/??? MDSC are more suppressive than BALB/c MDSC.

IL1B@Cytosol

Identifiers

Maps_Modules

References

IL1B@default

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. IL1B@Cytosol map
In compartment: default
  1. IL1B@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rIL1B@Cytosol map → map IL1B@Cytosol map
    2. IL1B@default map → map Proinflammatory chemokines and cytokines@default map
    3. IL1B@Cytosol map → map IL1B@Cytosol map
    4. IL1B@Cytosol map → map trILB1@Cytosol map
    As Catalyser: