Protein NLRP3
HUGO:NLRP3
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
PMID:19104081
Inflammasome is needfull for processing and release of IL-1beta in monocytes downstream of TLR2 or TLR4 signaling.
It contains CASP1, Pycard, NLRP3 (NALP3)

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Modifications:
Participates in complexes:
In compartment: Cytosol

1. Caspase1*:​NLRP3:​PYCARD@Cytosol
2. (NLRP3:​PYCARD:​cleaved Caspase1*)|​active@Cytosol

Participates in reactions:
As Reactant or Product:

1. Caspase1*:​NLRP3:​PYCARD@Cytosol → (NLRP3:​PYCARD:​cleaved Caspase1*)|​active@Cytosol

As Catalyser:

1. IL1B@Cytosol → trILB1@Cytosol