Protein NFKB1_p50* map

Identifiers
HUGO:NFKB1
MODULE:CAF
MODULE:CORE
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
HUGO:NFKB1 HGNC:7794 ENTREZ:4790 UNIPROT:P19838
MODULE:CORE_SIGNALING_PATHWAYS
MODULE:IMMUNOSTIMULATORY_CORE_PATHWAYS
HUGO:NFKB1 HGNC:7794 ENTREZ:4790 UNIPROT:P19838 GENECARDS:NFKB1 REACTOME:57855 KEGG:4790 ATLASONC:NFKB1ID323 WIKI:NFKB1

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / RCD_GENES  map
 Regulated Cell Death  map  / TNF_RESPONSE  map
 Regulated Cell Death  map  / ER_STRESS  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map

References
PMID:8383323
The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65
PMID:15079071
when T cells were stimulated with anti-CD3 antibody, RelA, c-Rel, and p50 were preferentially recruited to the IL-2 promoter
PMID:14668329
predominance of p50-p50 homodimers binding to the IL-2 promoter ??B site in tolerant T cells CD4+ correlated with repression of NF??B-driven transcription.
PMID:8580069
PMID:15536066
Signal-dependent nuclear translocation of p50 and p65 is impaired in PKC?????/??? cells.
PMID:20138012
NF-??B heterodimer (RelA-p50) translocates to the nucleus, where it activates the transcription of its target genes ( Karin and Ben-Neriah, 2000 and Pereira and Oakley, 2008). Nuclear p65 staining was detected in the stroma of HPV skin sections but not in the skin of nontransgenic control mice
PMID:23430059
PMID:19171876, PMID:17145890
NFkB p50/p50 homodimers (which lack the transactivation
domain) compete with canonical p65/p50 heterodimers for
the binding sites on the inflammatory
gene promoters, thereby blocking p65/p50 promoter
binding and gene transcription.
p50 NF-kappaB overexpression accounts for the
inability of tumor assasiated macrophages to mount
an effective M1 antitumor response capable of inhibiting tumor growth.
PMID:17404308
CSF1 downregulates TNF, IL-23p19, IL-12p40 expression probably via induction of acomulation of p50 homodimer and inhibition of p65/p50 NF-kB signaling.

NFKB1_p50*@T_cell

References
ad_re411( Adaptive Immune Response  map ):
PMID:17404308
CSF1 induces acomulation of p50 homodimer and inhibition of p65/p50 NF-kB signaling

NFKB1_p50*|​hm2@T_cell

References
ad_re411( Adaptive Immune Response  map ):
PMID:17404308
CSF1 induces acomulation of p50 homodimer and inhibition of p65/p50 NF-kB signaling

Modifications:
In compartment: T_cell
  1. NFKB1_p50*@T_cell map
  2. NFKB1_p50*|​hm2@T_cell map
Participates in complexes:
In compartment: T_cell
  1. NFKB1_p50*:​RELA@T_cell map
  2. NFKB1_p50*:​RELB@T_cell map
  3. NFKB1_p50*:​cREL*@T_cell map
  4. BCL3:​NFKB1_p50*|​hm2@T_cell map
  5. IkB*:​NFKB1_p50*:​RELA@T_cell map
  6. IkB*:​NFKB1_p50*:​RELB@T_cell map
  7. IkB*:​NFKB1_p50*:​cREL*@T_cell map
  8. IkB*|​pho:​NFKB1_p50*:​RELA@T_cell map
  9. IkB*|​pho:​NFKB1_p50*:​RELB@T_cell map
  10. IkB*|​pho:​NFKB1_p50*:​cREL*@T_cell map
Participates in reactions:
As Reactant or Product:
  1. IkB*:​NFKB1_p50*:​RELA@T_cell map → map IkB*|​pho:​NFKB1_p50*:​RELA@T_cell map
  2. IkB*:​NFKB1_p50*:​RELB@T_cell map → map IkB*|​pho:​NFKB1_p50*:​RELB@T_cell map
  3. IkB*:​NFKB1_p50*:​cREL*@T_cell map → map IkB*|​pho:​NFKB1_p50*:​cREL*@T_cell map
  4. NFKB1_p50*:​cREL*@T_cell map → map NFkB*@T_cell map
  5. NFKB1_p50*:​RELA@T_cell map → map NFkB*@T_cell map
  6. NFKB1_p50*@T_cell map → map NFKB1_p50*|​hm2@T_cell map
  7. NFKB1_p105*@T_cell map → map NFKB1_p50*@T_cell map
  8. IkB*@T_cell map + cREL*@T_cell map + NFKB1_p50*@T_cell map → map IkB*:​NFKB1_p50*:​cREL*@T_cell map
  9. IkB*@T_cell map + RELB@T_cell map + NFKB1_p50*@T_cell map → map IkB*:​NFKB1_p50*:​RELB@T_cell map
  10. IkB*@T_cell map + RELA@T_cell map + NFKB1_p50*@T_cell map → map IkB*:​NFKB1_p50*:​RELA@T_cell map
  11. IkB*|​pho:​NFKB1_p50*:​cREL*@T_cell map → map NFKB1_p50*:​cREL*@T_cell map + IkB*|​pho@T_cell map
  12. IkB*|​pho:​NFKB1_p50*:​RELB@T_cell map → map NFKB1_p50*:​RELB@T_cell map + IkB*|​pho@T_cell map
  13. IkB*|​pho:​NFKB1_p50*:​RELA@T_cell map → map NFKB1_p50*:​RELA@T_cell map + IkB*|​pho@T_cell map
  14. NFKB1_p50*|​hm2@T_cell map + BCL3@T_cell map → map BCL3:​NFKB1_p50*|​hm2@T_cell map
As Catalyser:
  1. NFkB*@T_cell map → map NFkB*@T_cell map
  2. gIL2@T_cell map → map rIL2@T_cell map
  3. gIL2RA@T_cell map → map rIL2RA@T_cell map
  4. gIFNG@T_cell map → map rIFNG@T_cell map