Identifiers
HUGO:NFKBIA HUGO:NFKBIB HUGO:NFKBIE
NFKB inhibitor alpha
HUGO:NFKBIA hgnc_id:HGNC:7797 HGNC:7797 ENTREZ:4792 UNIPROT:P25963
NFKB inhibitor beta
HUGO:NFKBIB hgnc_id:HGNC:7798 HGNC:7798 ENTREZ:4793 UNIPROT:Q15653
NFKB inhibitor epsilon
HUGO:NFKBIE hgnc_id:HGNC:7799 HGNC:7799 ENTREZ:4794 UNIPROT:O00221
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CORE
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
References
PMID:12133805
PMID:23086447, PMID:25305492, PMID:23422957
In canonical NFkB pathway RelB/p50, RelA/p50 and c-Rel/p50 heterodimers are sequestered by I??B-??, I??B-??, and I??B-??
MACROPHAGE
DENDRITIC_CELL
CASCADE:IL13
CASCADE:IL2
CASCADE:CSF2
CASCADE:TNF
PMID:10607713
Maturation of dendritic cells correlates with an increase in I??B??, I??B??, and Bcl-3
PMID:17550372, PMID:9743347
IL13 inhibits NFBB activation via inhibition of p65 nuclear migration in inflammatory macrophages and via prevention of degradation of IkBa (
→ IkB*|pho:NFKB1_p50*:RELA@T_cell
→ IkB*|pho:NFKB1_p50*:RELB@T_cell
→ IkB*|pho:NFKB1_p50*:cREL*@T_cell
+ cREL*@T_cell + NFKB1_p50*@T_cell → IkB*:NFKB1_p50*:cREL*@T_cell
+ RELB@T_cell + NFKB1_p50*@T_cell → IkB*:NFKB1_p50*:RELB@T_cell
+ RELA@T_cell + NFKB1_p50*@T_cell → IkB*:NFKB1_p50*:RELA@T_cell
→ NFKB1_p50*:cREL*@T_cell + IkB*|pho@T_cell
→ NFKB1_p50*:RELB@T_cell + IkB*|pho@T_cell
→ NFKB1_p50*:RELA@T_cell + IkB*|pho@T_cell
→ degraded