Protein BCL3 map

Identifiers
HUGO:BCL3

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / MIRNA_TF_IMMUNOSUPPRESSIVE  map

References
PMID:14668329
PMID:15465827
BCL3 inhibits expression of IL1A, IL1B,TNF and positively regulates
IL-10 expression. BCL3 forms complex with HDAC1 and
repression of the TNF promoter by BCL3
requires Histone Deacetylase Activity.
PMID:12907458
Bcl-3??? ???interacted with NF-??B p50,
both Bcl-3??? ???and p50??? ???were recruited to the TNF promoter,
BCL3??? ??? and??? ???p50??? ???NFkB recruitment to??? ???TNF ???promoter
prevents binding of??? ???p65/p50??? ???NFkB??? ???heterodimers
to??? ???TNF promotor and suppresses??? ???TNF ???expression
downstream of??? ???IL10.

Modifications:
In compartment: T_cell
  1. BCL3@T_cell map
Participates in complexes:
In compartment: T_cell
  1. BCL3:​NFKB1_p50*|​hm2@T_cell map
Participates in reactions:
As Reactant or Product:
  1. NFKB1_p50*|​hm2@T_cell map + BCL3@T_cell map → map BCL3:​NFKB1_p50*|​hm2@T_cell map
As Catalyser:
  1. gIL2@T_cell map → map rIL2@T_cell map