Protein cREL* map

Identifiers
HUGO:REL

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
PMID:8383323 PMID:10221648 PMID:15079071
 DENDRITIC_CELL  map
CASCADE:VEGFA
PMID:2308644
Relb transcripts were reduced by ~40% in Rel???/??? relative to wild-type BMDC
Quantitative RT-PCR validated the requirements of RelB and c-Rel in activating Cxcl2, Cd40 and Il1b gene expression
PMID:25305492
p19 and p40 subunits of IL-23, a c-Rel-dependent cytokine, was enhanced in p100-deficient cells, although expression of a RelA-dependent cytokine, TNF-??, was reduced. Nuclear translocation of c-Rel was enhanced in p100-deficient cells. p100, and not the processed p52 form, associated with c-Rel in the steady state and dissociated immediately after lipopolysaccharide stimulation in wild-type dendritic cells. Four hours after the stimulation, p100 was newly synthesized and associated with c-Rel again. In cells expressing both c-Rel and RelA, c-Rel is preferentially suppressed by p100.

Modifications:
In compartment: T_cell
  1. cREL*@T_cell map
Participates in complexes:
In compartment: T_cell
  1. NFKB1_p50*:​cREL*@T_cell map
  2. IkB*:​NFKB1_p50*:​cREL*@T_cell map
  3. IkB*|​pho:​NFKB1_p50*:​cREL*@T_cell map
Participates in reactions:
As Reactant or Product:
  1. IkB*:​NFKB1_p50*:​cREL*@T_cell map → map IkB*|​pho:​NFKB1_p50*:​cREL*@T_cell map
  2. NFKB1_p50*:​cREL*@T_cell map → map NFkB*@T_cell map
  3. IkB*@T_cell map + cREL*@T_cell map + NFKB1_p50*@T_cell map → map IkB*:​NFKB1_p50*:​cREL*@T_cell map
  4. IkB*|​pho:​NFKB1_p50*:​cREL*@T_cell map → map NFKB1_p50*:​cREL*@T_cell map + IkB*|​pho@T_cell map
As Catalyser:
  1. gIL2@T_cell map → map rIL2@T_cell map
  2. gIL2RA@T_cell map → map rIL2RA@T_cell map