Reaction truncation em_emtc_emtc_re228 map

LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map → TGFB1|​hm2|​active@Extracellular space map + LTBP1:​Latency-associated protein*|​hm2@Extracellular space map

Reaction regulators:
Catalysis
  1. THBS1@Extracellular space map
  2. MMP9*@Extracellular space map
  3. MMP13*@Extracellular space map
  4. MMP2*@Extracellular space map


Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
PMID:21900405
MMP13 activates TGFB by cleavage of LAP
Plasmin activates TGFB by cleavage of LAP
MMP9 activates TGFB by cleavage of LAP
Integrin aVb6 activates the ECM-bound latent TGFB1 and TGFB3 by traction
Integrin aVb8 and MMP14 (so-called MT1-MMP) cooperate to activate the ECM-bound latent TGFB1 and TGFB3:
-Integrin aVb8 binds LAP from the large latent complex
-MMP14 then is recruited to cleave LAP