Protein MMP9* map

Identifiers
HUGO:MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
HUGO:MMP9, HGNC:7176, ENTREZ:4318, UNIPROT:P14780, GENECARDS:GC20P044637??

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

MMP9*@default

References
mo_re254:( motility  map ) PMID:27328425 PMID:27572739 PMID:27510662
mo_re255:( motility  map ) PMID:27328425 PMID:27510662

MMP9*@Extracellular space

References
em_emtc_emtc_re228( EMT Senescence  map ):
PMID:21900405
MMP13 activates TGFB by cleavage of LAP
Plasmin activates TGFB by cleavage of LAP
MMP9 activates TGFB by cleavage of LAP
Integrin aVb6 activates the ECM-bound latent TGFB1 and TGFB3 by traction
Integrin aVb8 and MMP14 (so-called MT1-MMP) cooperate to activate the ECM-bound latent TGFB1 and TGFB3:
-Integrin aVb8 binds LAP from the large latent complex
-MMP14 then is recruited to cleave LAP

Modifications:
In compartment: Extracellular space
  1. MMP9*@Extracellular space map
In compartment: default
  1. MMP9*@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. MMP9@Extracellular space map → map MMP9*@Extracellular space map
    2. MMP9@default map → map MMP9*@default map
    3. MMP9*@default map → map Invasion@default map
    As Catalyser:
    1. Galectin 3*@Extracellular space map → map truncated Galectin 3*@Extracellular space map
    2. Elastin*@Extracellular space map → map Truncated Elastin*@Extracellular space map
    3. COL2A1@Extracellular space map → map Collagen2*@Extracellular space map
    4. Collagen4*@Extracellular space map → map Truncated Collagen4*@Extracellular space map
    5. LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map → map TGFB1|​hm2|​active@Extracellular space map + LTBP1:​Latency-associated protein*|​hm2@Extracellular space map