Complex LTBP1:Latency-associated protein* map
Complex composition:

  1. Latency-associated protein* map
  2. LTBP1 map

LTBP1:​Latency-associated protein*|​hm2@Extracellular space

Identifiers
NAME:LTBP1:Latency-associated protein*

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
em_emtc_emtc_re228( EMT Senescence  map ):
PMID:21900405
MMP13 activates TGFB by cleavage of LAP
Plasmin activates TGFB by cleavage of LAP
MMP9 activates TGFB by cleavage of LAP
Integrin aVb6 activates the ECM-bound latent TGFB1 and TGFB3 by traction
Integrin aVb8 and MMP14 (so-called MT1-MMP) cooperate to activate the ECM-bound latent TGFB1 and TGFB3:
-Integrin aVb8 binds LAP from the large latent complex
-MMP14 then is recruited to cleave LAP

Modifications:
Participates in complexes:
In compartment: Extracellular space
  1. LTBP1:​Latency-associated protein*|​hm2@Extracellular space map
Participates in reactions:
As Reactant or Product:
  1. LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space map → map TGFB1|​hm2|​active@Extracellular space map + LTBP1:​Latency-associated protein*|​hm2@Extracellular space map
As Catalyser: